• Hippocampal growth hormone modulates relational memory and the dendritic spine density in CA1 

      Haugland, Kamilla Gjerland; Olberg, Anniken; Lande, Andreas; Kjelstrup, Kirsten Brun; Brun, Vegard Heimly (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02)
      Growth hormone (GH) deficiency is associated with cognitive decline which occur both in normal aging and in endocrine disorders. Several brain areas express receptors for GH although their functional role is unclear. To determine how GH affects the capacity for learning and memory by specific actions in one of the key areas, the hippocampus, we injected recombinant adeno-associated viruses (rAAVs) ...
    • Hippocampal plasticity: Development of connectivity and growth hormone modulation of place cells and behavior 

      Haugland, Kamilla Gjerland (Doctoral thesis; Doktorgradsavhandling, 2021-06-17)
      The hippocampus is remarkably plastic and has the ability to modify its processes throughput the lifetime. During development, the hippocampus is exceedingly plastic as new neurons and connections are taking form. Nevertheless, the neural circuits of the hippocampus keep modifying in the adult. The factors contributing to hippocampal plasticity are still elusive. In this thesis, I present three ...